Prof Goodhill originally trained in Mathematics, Physics, Artificial Intelligence and Cognitive Science at Bristol, Sussex and Edinburgh Universities. After postdoctoral work at the Salk Institute he started his own lab in the Neuroscience Department at Georgetown University Medical School, where he was awarded tenure. In 2005 he moved to Australia to take up a joint appointment between the Queensland Brain Institute and School of Mathematics and Physics at the University of Queensland in Brisbane. In 2021 he returned to the US to the departments of Developmental Biology and Neuroscience at Washington University School of Medicine, where he directs the new Center for Theoretical and Computational Neuroscience.

Prof Goodhill has been awarded over 30 grants to fund his research from the NIH, NSF, DoD, Simons Foundation, Human Frontiers Science Foundation, Whitaker Foundation, Australian Research Council, and Australian National Health and Medical Research Council. He has trained over 30 PhD students and postdocs, many of whom are now faculty members in universities worldwide. From 2005-2010 he was Editor-in-Chief of the journal Network: Computation in Neural Systems, and has also served on the Editorial Boards of several other journals. In 2006 he founded the Australian Workshop on Computational Neuroscience and in 2015 the Systems and Computational Neuroscience DownUnder (SCiNDU) conference, which have both run regularly since then. He has taught courses in Medical Neuroscience, Systems Neuroscience, Developmental Neuroscience, Mathematical Neuroscience, Numerical Methods, and Scientific Computing. Besides giving many radio interviews and public lectures about his work he has also written several articles for The Conversation and given a TEDx talk.